digoxin immune fab digifab logo DIGIFab

DIGIFab Video Resources for Healthcare Professionals

Watch to learn more about the signs of digoxin toxicity and how DIGIFab works to rapidly resolve the clinical manifestations of potentially life-threatening digoxin toxicity.

Appropriate Dosing and Administration

Learn more about dosing DIGIFab based on a patient’s clinical condition and amount of digoxin to be neutralized.

A Drug-Drug Interaction Leading to Life-Threatening Digoxin Toxicity: A Patient Case Study

Jason Hack, MD 

Emergency Medicine Physician and Medical Toxicologist 

Vice Chair of Research and Division Chief of Medical Toxicology, Department of Emergency Medicine

Join Dr. Jason Hack as he reviews an illustrative patient case based on his clinical experience treating potentially life-threatening digoxin toxicity.

A Patient Case Study With Dr. Michael Martino

Michael Martino, MD 

Emergency Medicine Physician

Watch emergency medicine physician Dr. Michael Martino walk through how he recognized potentially life-threatening digoxin toxicity in his patient and the steps he took to rapidly resolve the toxic effects.

Expert Clinical Insight – Recognizing and Resolving Potentially Life-Threatening Digoxin Toxicity With Dr. Jason Hack 

Jason Hack, MD

Emergency Medicine Physician and Medical Toxicologist 

Vice Chair of Research and Division Chief of Medical Toxicology, Department of Emergency Medicine

Watch Dr. Jason Hack share an in-depth overview of the signs and symptoms of digoxin toxicity and the importance of treating early with DIGIFab.

Don’t have time to watch the full video? View clips below to jump to specific sections.



From the Science to the Symptoms: Understanding Potentially Life-Threatening Digoxin Toxicity

Connect the signs and symptoms of potentially life-threatening digoxin toxicity to the underlying biological mechanisms and enhance your understanding of digoxin toxicity.

Life-Threatening Digoxin Toxicity

Review clues that may point to potentially life-threatening digoxin toxicity and the importance of immediate intervention.

Why DIGIFab?

Watch a brief overview of DIGIFab, THE antidote for digoxin toxicity with over 20 years of clinical experience.1-3

Understanding the Mechanism of Action of DIGIFab

See how DIGIFab neutralizes free digoxin within minutes to resolve the cardiotoxic effects and other manifestations of potentially life-threatening digoxin toxicity.1,4


  1. DIGIFab Digoxin Immune Fab (ovine) [package insert]. BTG International Inc.; 2017.
  2. Dart RC, Goldfrank LR, Erstad BL, et al. Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care. Ann Emerg Med. 2018;71(3):314-325.
  3. Levine MD, O’Connor A. Digitalis (cardiac glycoside) poisoning. UpToDate. Updated January 2020. Accessed October 1, 2021. https://www.uptodate.com/contents/digitalis-cardiac-glycoside-poisoning
  4. Ward SB, Sjostrom L, Ujhelyi MR. Comparison of the pharmacokinetics and in vivo bioaffinity of DigiTAb versus Digibind. Ther Drug Monit. 2000;22(5):599-607.


DIGIFab is indicated for the treatment of patients with life-threatening or potentially life-threatening digoxin toxicity or overdose, including:

  • Known suicidal or accidental consumption of fatal doses of digoxin: 10 mg or more of digoxin in healthy adults, or 4 mg (or more than 0.1 mg/kg) in healthy children, or ingestion of an amount that can cause steady state serum concentrations of ≥10 ng/mL;
  • Chronic ingestions causing steady-state serum digoxin concentrations >6 ng/mL in adults or 4 ng/mL in children;
  • Manifestations of life-threatening toxicity of digoxin overdose such as severe ventricular arrhythmias, progressive bradycardia, and second or third degree heart block not responsive to atropine, serum potassium levels exceeding 5.5 mEq/L in adults or 6 mEq/L in children with rapidly progressive signs and symptoms of digoxin toxicity.


Warnings and Precautions


Suicidal ingestion may result from more than one drug. Consider toxic effects of other drugs or poisons in cases where signs and symptoms of digitalis toxicity are not relieved by administration of DIGIFab.

Rapid drop in serum potassium concentration may occur after treatment. Monitor frequently.

Patients with poor cardiac function may deteriorate secondary to the withdrawal of the inotropic action of digoxin by DIGIFab. Monitor frequently and provide additional inotropic support if needed. Postpone re-digitalization, if possible, until the Fab fragments have been eliminated; this may require several days or a week or longer in patients with impaired renal function.

Hypersensitivity Reactions

Anaphylaxis and hypersensitivity reactions are possible. Carefully monitor patients for signs and symptoms of an acute allergic reaction and if one occurs, stop the infusion and treat immediately with appropriate emergency medical care.

Patients with known allergies to sheep protein or those who have previously received intact ovine antibodies or Fab are particularly at risk for an anaphylactic reaction.

Do not administer DIGIFab to patients with a known history of hypersensitivity to papaya or papain unless the benefits outweigh the risks and appropriate management for anaphylactic reactions is readily available.

Use of DIGIFab in Renal Failure

The elimination half-life of DIGIFab in renal failure has not been clearly defined. Monitor patients with severe renal failure who receive DIGIFab for a prolonged period for possible recurrence of toxicity. Monitoring of free (unbound) digoxin concentrations after the administration may be appropriate.

Laboratory Tests

DIGIFab may interfere with digitalis immunoassay measurements. Thus, standard serum digoxin concentration measurements may be clinically misleading until the Fab fragments are eliminated from the body. This may take several days or a week or more in patients with markedly impaired renal function. If possible, obtain serum digoxin samples before DIGIFab administration to establish the level of serum digoxin at the time of diagnosis.

The total serum digoxin concentration may rise precipitously following administration of DIGIFab, but this will be almost entirely bound to the Fab fragment and not able to react with receptors in the body.

Adverse Reactions

The most common adverse reactions (>7%) related to DIGIFab administration are worsening congestive heart failure (13%), hypokalemia (13%) and worsening atrial fibrillation (7%).

Please see full Prescribing Information.