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Digoxin Toxicity Can Be Fatal

  • Digoxin toxicity (or digoxin poisoning) may result in serious clinical
    outcomes, including death.1-3
  • In-hospital and 30-day mortality rates from digoxin toxicity remain high,
    despite declining use of digoxin overall.1

In-hospital and 30-day mortality rates, 1999-20131

digoxin toxicity mortality rates chart

Percentage of patients from a national cohort of Medicare fee-for-service beneficiaries aged ≥65 years in the United States who were hospitalized with a diagnostic code for digoxin toxicity between January 1, 1999, and December 31, 2013 (21,331 unique patients contributing 420,390,283 person-years).

Understanding Potentially Life-Threatening Digoxin Toxicity

See how digoxin can lead to potentially life-threatening toxicity and understand signs and symptoms to look for.


  1. Angraal S, Nuti SV Masoudi FA. Digoxin use and associated adverse events among older adults. Am J Med. 2019;132(10):1191-1198.
  2. Goldberger AL, Traub SJ. Cardiac arrhythmias due to digoxin toxicity. UpToDate. Updated January 2020. https://www.uptodate.com/contents/cardiac-arrhythmias-due-to-digoxin-toxicity. Accessed December 2023.
  3. Levine MD, O’Connor A. Digitalis (cardiac glycoside) poisoning. UpToDate. Updated January 2020. https://www.uptodate.com/contents/digitalis-cardiac-glycoside-poisoning. Accessed December 2023.
  4. Royal College of Emergency Medicines and National Poisons Information Service Guideline on Antidote Availability for Emergency Departments. Available at: https://rcem.ac.uk/clinical-guidelines/ Accessed December 2023.