Prescribing Information Summary of Product Characteristics
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Risk Factors

Raise the Index of Clinical Suspicion

  • Patients undergoing digoxin therapy who exhibit risk factors for digoxin toxicity should be closely monitored so that any signs of poisoning are identified early to ensure timely treatment.1

Risk factors for potentially life-threatening digoxin toxicity

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Decreased Renal Function1,2

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Renal impairment can lead to increased digoxin levels, as digoxin is primarily eliminated by the kidneys1,2

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Multiple Concomitant Medications2

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Many medications can cause pharmacokinetic and pharmacodynamic interactions with digoxin or a decrease in renal function2

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Advanced Age and Medical Illness2-4

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Older patients are more likely to have decreased renal function and to be taking interacting concomitant medications2,3; advanced heart failure is also associated with decreased renal function4

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Electrolyte Imbalance1,5

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Certain electrolyte imbalances (e.g., hypokalaemia, hypercalcemia, hypomagnesemia) can increase sensitivity to digoxin effects1,5,*

*In patients with toxicity from acute ingestion, hyperkalaemia is associated with high mortality1

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Fluid Status1

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Fluid loss or poor fluid intake can lead to electrolyte imbalance1

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Any ONE
should raise clinical suspicion for
LIFE-THREATENING DIGOXIN TOXICITY1,3

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For known (or strongly suspected) life-threatening
digoxin toxicity, think R.A.P.I.D.1,2,5

Recognize. Act. Promptly Infuse DIGIFab®.

View Efficacy Data

* DIGIFab® is indicated for the treatment of known (or strongly suspected) life-threatening digoxin toxicity associated with ventricular arrhythmias or bradyarrhythmias unresponsive to atropine where measures beyond withdrawal of digoxin and correction of serum electrolyte abnormalities are considered necessary.5

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DIGIFab® rapidly neutralises free digoxin to resolve the cardiotoxic effects and other clinical manifestations of life-threatening digoxin toxicity5,6

See How DIGIFab® Works

References

  1. Levine MD, O’Connor A. Digitalis (cardiac glycoside) poisoning. UpToDate. Updated January 2020. https://www.uptodate.com/contents/digitalis-cardiac-glycoside-poisoning. Accessed December 2023.
  2. Wofford JL, Ettinger WH. Risk factors and manifestations of digoxin toxicity in the elderly. Am J Emerg Med. 1991;9(2):11-15.
  3. Goldberger AL, Traub SJ. Cardiac arrhythmias due to digoxin toxicity. UpToDate. Updated January 2020. https://www.uptodate.com/contents/cardiac-arrhythmias-due-to-digoxin-toxicity. Accessed December 2023. 
  4. McAlister FA, Ezekowitz A, Tonelli M, Armstrong PW. Renal insufficiency and heart failure: Prognostic and therapeutic implications from a prospective cohort study. Circulation. 2004;109(8):1004-1009.
  5. DIGIFab Digoxin Immune Fab (ovine) [summary of product characteristics]. Protherics UK Limited; 2017.
  6. Ward SB, Sjostrom L, Ujhelyi MR. Comparison of the pharmacokinetics and in vivo bioaffinity of DigiTAb versus Digibind. Ther Drug Monit. 2000;22(5):599-607.